Reword this paragraph! Easy points! :)?"For smokers with unrestricted access to cigarettes there may be few adverse fetal consequences to substituting a transdermal patch for smoking because most tobacco users maintain their smoking to achieve a steady-state plasma level of nicotine. Replacement therapy would have the benefit of removing the additional injurious substances found in cigarette smoke. However, for smokers who spend their day in an environment where smoking is restricted nicotine intake may resemble an episodic exposure model, with relative protection of the fetus. In these smokers, especially if they smoke only small amounts, it is possible that greater fetal injury may result from the use of high-dose nicotine patches; accordingly, for this population, the total daily nicotine dose, whether delivered by smoking or by replacement therapy, should be considered carefully. In any case, some obvious rules can be applied, based solely on the recognition that nicotine injures the fetal brain through receptor-mediated mechanisms. Then, if patches are used they should be introduced early in pregnancy, with an attempt to discontinue use by the second trimester, assuming, of course, that compliance with smoking cessation will be maintained. Lower doses should be preferred and women should be encouraged to remove the patch overnight to permit plasma levels to decay from the steady-state"
Aubrey A
For smokers with unrestricted access to cigarettes, substituting a transdermal patch for smoking may have few adverse fetal consequences. This is because most tobacco users maintain their smoking to achieve a steady-state plasma level of nicotine, and replacement therapy would have the benefit of removing the additional harmful substances found in cigarette smoke. However, for smokers that spend their day in an environment where smoking is restricted, using a high-dose nicotine patch may resemble an episodic exposure model. This may cause greater fetal injury due to taking in more nicotine from the patch, especially if they smoke only small amounts. Accordingly, the total daily nicoting dose, whether delivered by smoking or replacement therapy, should be carefully considered. In any case, it is important to recognize that nicotine injures the fetal brain through receptor-mediated mechanisms. If there is an attempt to quit smoking during pregnacy by using nicotine patches, they should be introduced early in the pregnancy, with an attempt to discontine use by the second trimester. This is assuming that compliance with smoking cessation will be maintained. It is important to use lower doses during the time of pregnancy, and women are encouraged to remove the patch overnight to permit plasma levels to decay from the steady-state.
Orignal From: Reword this paragraph! Easy points! :)?
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